C4749
Carboxylesterase 2 human
recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)
Synonyme(s) :
CES2, CES2A1
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About This Item
Produits recommandés
Produit recombinant
expressed in mouse NSO cells
Niveau de qualité
Pureté
≥95% (SDS-PAGE)
Forme
solution
Activité spécifique
≥1.0 EU/μg
30,000 pmol/min-μg protein
Poids mol.
predicted mol wt ~60 kDa
Concentration
0.4-0.6 mg/mL
Impuretés
≤1.0 EU/μg endotoxin
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... CES2(8824)
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Actions biochimiques/physiologiques
Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.
Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.
Définition de l'unité
One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C.
Forme physique
Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Resp. Sens. 1
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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