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C4490

Sigma-Aldrich

Anti-Caveolin-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Caveolin-1, Anti-VIP21

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About This Item

Numéro MDL:
MFCD01633097
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 22 kDa

Espèces réactives

human, rat, mouse

Technique(s)

indirect immunofluorescence: 4-8 μg/mL using HUVEC cell line
indirect immunofluorescence: suitable
western blot: 1-2 μg/mL using whole cell extract of the human endothelial ECV304 cell line and the mouse fibroblast NIH3T3 cell line

Numéro d'accès UniProt

Q03135

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)

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Description générale

Caveolin, a 20-24 kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (CAV1) (20- 22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA. Caveolin-1 and -2 have similar tissue distribution.

Spécificité

The sequence is highly conserved in many species, e.g., identical in rat, mouse, bovine, and dog caveolin-1. The sequence is not found in caveolin-2 or caveolin-3.

Immunogène

synthetic peptide corresponding to a region at the N-terminus of human caveolin-1 (amino acids 2-20).

Application

Anti-Caveolin-1 antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Actions biochimiques/physiologiques

Caveolin can simultaneously recognize GPI-linked proteins and interact directly with a number of caveolae associated downstream signaling molecules, such as H-Ras, hetero-trimeric G-proteins, annexin-II, epidermal growth factor receptor (EGFR), protein kinase C, src-family tyrosine kinases and nitric oxide synthase (NOS) isoforms. Caveolin-1 participates in angiogenesis and is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism by controlling the expression of glucose transporters.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Ingrid R Niesman et al.
Molecular and cellular neurosciences, 56, 283-297 (2013-07-16)
Microglia are ramified cells that serve as central nervous system (CNS) guardians, capable of proliferation, migration, and generation of inflammatory cytokines. In non-pathological states, these cells exhibit ramified morphology with processes intermingling with neurons and astrocytes. Under pathological conditions, they
Fan Deng et al.
Oxidative medicine and cellular longevity, 2017, 3542149-3542149 (2017-11-29)
Endothelial microvesicles (EMVs), released after endothelial cell (EC) apoptosis or activation, may carry many adverse signals and propagate injury by intercellular transmission. Caveolae are 50-100 nm cell surface plasma membrane invaginations involved in many pathophysiological processes. Recent evidence has indicated EMVs
Brian C Russo et al.
mBio, 10(3) (2019-05-30)
Many Gram-negative bacterial pathogens require a type 3 secretion system (T3SS) to deliver effector proteins into eukaryotic cells. Contact of the tip complex of the T3SS with a target eukaryotic cell initiates secretion of the two bacterial proteins that assemble
Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
Yun JH, et al.
Experimental & Molecular Medicine, 43(12), 660-660 (2011)
Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes
Fernandez RJM, et al.
Nutrition & Metabolism, 7(1), 20-20 (2010)
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