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C4116

Sigma-Aldrich

Cyclopamine hydrate

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

Synonyme(s) :

11-deoxojervine hydrate

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About This Item

Formule empirique (notation de Hill):
C27H41NO2 · xH2O
Numéro CAS:
1217465-07-0
Poids moléculaire :
411.62 (anhydrous basis)
Code UNSPSC :
12352116
ID de substance PubChem :
24724439
Nomenclature NACRES :
NA.77

Nom du produit

Cyclopamine hydrate, ≥98% (HPLC)

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

solid

Couleur

white

Solubilité

DMSO: soluble ≥5 mg/mL
H2O: insoluble

Température de stockage

2-8°C

Chaîne SMILES 

O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1

InChI

1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1

Clé InChI

KDAGJRDPNXDDSB-HBYCUIHISA-N

Informations sur le gène

human ... EBP(10682)

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Description générale

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Application

Cyclopamine hydrate has been used:
  • as a sonic hedgehog (Shh) inhibitor in various experiments
  • to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
  • to study its influence on ocular vessel patterning

Actions biochimiques/physiologiques

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
095M4702V
104M4750V
101M4724V
021M4704V
039K47212

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