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Key Documents

C1728

Sigma-Aldrich

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-CACH3, Anti-CACN4, Anti-CACNL1A2, Anti-CCHL1A2, Anti-Cav1.3, Anti-PASNA, Anti-SANDD

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About This Item

Numéro MDL:
MFCD02095953
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse, rat

Technique(s)

immunocytochemistry: 1:30-1:150
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:100-1:200

Numéro d'accès UniProt

Q99246

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CACNA1D(776)
mouse ... Cacna1d(12289)
rat ... Cacna1d(29716)

Immunogène

synthetic peptide corresponding to amino acids 859-875 of rat α1D (Accession P27732). This epitope is highly conserved in human and hamster.

Application

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:
  • immunocytochemistry at a dilution of 1:30-1:150
  • immunoprecipitation
  • western blot (chemiluminescent) at a dilution of 1:100-1:200

Actions biochimiques/physiologiques

Cav1.3 also known as the calcium channel, voltage-dependent, L type, α1D subunit (CACNA1D), is a human gene. It responds more sensitively to depolarization than those of Cav1.2 or Cav3.1. Cav1.3 is required for proper hearing as well as sinoatrial node and brain function. It undergoes extensive alternative splicing. Alternative splicing in the C terminus and drastically modifies gating properties of the channel. The L-type calcium channel Cav1.3 is important in human glucose-induced insulin secretion and common variants in CACNA1D may contribute to type 2 diabetes.

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Hua Huang et al.
Molecular pharmacology, 84(4), 643-653 (2013-08-09)
The transcripts of L-type voltage-gated calcium channels (CaV) 1.3 undergo extensive alternative splicing. Alternative splicing, particularly in the C terminus, drastically modifies gating properties of the channel. However, little is known about whether alternative splicing could modulate the pharmacologic properties
Pi-Cheng Cheng et al.
Journal of biomedical science, 25(1), 44-44 (2018-05-24)
Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca2+ exchanger (NCX) and mitochondria play a role in regulating intracellular Ca2+
Jan Salomonsen et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8668-8673 (2005-06-09)
CD1 molecules play an important role in the immune system, presenting lipid-containing antigens to T and NKT cells. CD1 genes have long been thought to be as ancient as MHC class I and II genes, based on various arguments, but
Allison Sargoy et al.
PloS one, 9(1), e84507-e84507 (2014-01-15)
Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy. Since calcium has dual roles in maintaining homeostasis and triggering apoptotic pathways in healthy and
A Hui et al.
Neuron, 7(1), 35-44 (1991-07-01)
Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an
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