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Key Documents

C0493

Sigma-Aldrich

Monoclonal Anti-Calcium Sensing Receptor from mouse

clone HL1499 (6D4-3F4-6C4), purified from hybridoma cell culture

Synonyme(s) :

Anti-CAR, Anti-EIG8, Anti-FHH, Anti-FIH, Anti-GPRC2A, Anti-HHC, Anti-HHC1, Anti-HYPOC1, Anti-NSHPT, Anti-PCAR1, Anti-hCasR

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About This Item

Numéro MDL:
MFCD02262635
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

HL1499 (6D4-3F4-6C4), monoclonal

Forme

buffered aqueous solution

Espèces réactives

rabbit, rat, mouse, human

Technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 3-6 μg/mL using total extract from rat kidney

Isotype

IgG1

Numéro d'accès UniProt

P41180

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CASR(846)
mouse ... Casr(12374)
rat ... Casr(24247)

Description générale

The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.

Immunogène

peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.

Application

Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:
  • Indirect ELISA
  • Immunoblotting
  • Immunocytochemistry
  • Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
  • Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney
Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.

Actions biochimiques/physiologiques

Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease.
Emanuela G, et al.
Frontiers in Neuroscience, 2017-2017 null
Calcium-Sensing Receptors
Goodman WG, et al.
Seminars in Nephrology, 24, 17-24 (2004)
Julio Cortijo et al.
Chemico-biological interactions, 183(1), 25-33 (2009-09-29)
Environmental exposure to nickel is associated to respiratory disorders and potential toxicity in the lung but molecular mechanisms remain incompletely explored. The extracellular Ca(2+)-sensing receptor (CaSR) is widely distributed and may be activated by divalent cations. In this study, we
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.
Catia V V, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1853(10), 2621-2628 (2015)
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells
Vaz CV, et al.
Biochimica et Biophysica Acta, 1853, 2621-2628 (2015)
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