Accéder au contenu
Merck
Toutes les photos(3)

Principaux documents

Voir toute la documentation

B8684

Sigma-Aldrich

Bambuterol hydrochloride

>98% (HPLC), powder

Synonyme(s) :

Dimethylcarbmic acid 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(3)

About This Item

Formule linéaire :
C18H29N3O5 · HCl
Numéro CAS:
81732-46-9
Poids moléculaire :
403.90
Numéro MDL:
MFCD03427293
Code UNSPSC :
12352200
ID de substance PubChem :
329773137
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

>98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

off-white

Solubilité

H2O: soluble ~33 mg/mL

Auteur

AstraZeneca

Chaîne SMILES 

Cl.CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C

InChI

1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H

Clé InChI

LBARATORRVNNQM-UHFFFAOYSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Bambuterol is present in various tissues, like , intestine, lungs, liver and heart. It is also found in serum.

Application

Bambuterol hydrochloride has been used as a β2-adrenergic receptor (β2-AR) agonist to study its effects on graft versus host disease (GVHD) while preserving the graft-versus-tumor (GvT) effect. It has also been used in the preparation of bambuterol-poly vinyl chloride (Bb-PVC) membrane sensors for the determination of bambuterol in the pharmaceutical dosage form.

Actions biochimiques/physiologiques

Bambuterol hydrochloride is used for prophylaxis and also to treat chronic bronchitis and chronic asthma in pediatrics.
β-adrenoceptor agonist; bronchodilator; anti-asthmatic; terbutaline prodrug

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
079K4700V
079K47001
079K4700
086K4715
093K4701

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Yejin Jang et al.
Viruses, 12(5) (2020-05-30)
Influenza A virus, one of the major human respiratory pathogens, is responsible for annual seasonal endemics and unpredictable periodic pandemics. Despite the clinical availability of vaccines and antivirals, the antigenic diversity and drug resistance of this virus makes it a
PVC membrane sensors for potentiometric determination of bambuterol in pharmaceutical formulation
Ezzeldin E, et al.
International Journal of Electrochemical Science, 7(11), 10570-10581 (2012)
Hemn Mohammadpour et al.
JCI insight, 5(12) (2020-05-22)
Acute graft versus host disease (aGvHD) remains a major impediment to successful allogeneic hematopoietic cell transplantation (allo-HCT). To solve this problem, a greater knowledge of factors that regulate the differentiation of donor T cells toward cytotoxic cells or Tregs is
J Rosenborg et al.
British journal of clinical pharmacology, 49(3), 199-206 (2000-03-16)
The pharmacokinetics of orally administered bambuterol were investigated in healthy adult subjects, with particular regard to time to steady state, pharmacokinetic linearity, intraindividual variability for the parent drug and its active beta2-adrenergic metabolite terbutaline and bioequivalence between tablet and solution.
Ting Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 38-44 (2015-06-21)
A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for simultaneous chiral analysis of an antiasthma drug bambuterol, its key intermediate monocarbamate bambuterol and its active drug terbutaline in human plasma. All samples were extracted with ethyl acetate
Afficher tous les articles scientifiques apparentés

Contenu apparenté

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique