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Principaux documents

B3398

Sigma-Aldrich

Anti-Human IgG2−Biotin antibody, Mouse monoclonal

clone HP-6014, purified from hybridoma cell culture

Synonyme(s) :

Monoclonal Anti-Human IgG2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Niveau de qualité

200

Conjugué

biotin conjugate

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

secondary antibodies

Clone

HP-6014, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

direct ELISA: 1:30,000

Isotype

IgG1

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

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Catégories apparentées

Description générale

Monoclonal Anti-Human IgG2 (mouse IgG1 isotype) is derived from the hybridoma (HP-60141 ) produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. IgG is the most abundant serum immunoglobulins of the immune system. IgG2 is a subtype of IgG. IgG is secreted by B cells and is found in blood and extracellular fluids.

Spécificité

The antibody is specific for human IgG2 and is non-reactive with other IgG subclasses. This clone has been singled out as the most widely applicable IgG2 specific monoclonal antibody by the IUIS/WHO study.

Application

Monoclonal Anti-Human IgG2−Biotin antibody produced in mouse has been used in indirect enzyme linked immunosorbent assay (ELISA) and immunoblot.

Actions biochimiques/physiologiques

IgG provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
Low IgG2 levels were found in patients with systemic lupus erythematosus (SLE) and juvenile diabetes melitus.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
069M4888V
22190408
019M4882V
058M4835V
22180148

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Placental transfer of IgG subclasses in a Japanese population
Hashira S, et al.
Pediatrics International, 42, 337-342 (2000)
Alberts B, et al.
Molecular biology of the Cell. 4th Edition., 42, 337-342 (2002)
Immunoglobulin subclass deficiency
Hanson L A, et al.
The Pediatric Infectious Disease Journal, 7, 7-21 (1988)
Elana R Shaw et al.
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To clinically characterize patients with anti-metabotropic glutamate receptor (mGluR) 1 encephalitis, to identify prognostic factors, and to study the immunoglobulin G (IgG) subclasses and effects of antibodies on neuronal mGluR1 clusters. Clinical information on new and previously reported patients was
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