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Key Documents

AV47141

Sigma-Aldrich

Anti-ZDHHC17 (AB1) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-HIP14, Anti-HIP3, Anti-HSPC294, Anti-HYPH, Anti-KIAA0946, Anti-Zinc finger, DHHC-type containing 17

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

73 kDa

Espèces réactives

rat, human, mouse, bovine, guinea pig, horse, rabbit, dog

Concentration

0.5 mg - 1 mg/mL

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_056151

Numéro d'accès UniProt

Q8IUH5

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ZDHHC17(23390)

Immunogène

Synthetic peptide directed towards the middle region of human ZDHHC17

Application

Anti-ZDHHC17 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

Actions biochimiques/physiologiques

ZDHHC17 is a palmitoyl acyl transferase (PAT) expressed primarily in insulin-positive cells in islets of Langerhans. Overexpression of HIP14 is related to a reduction in IL-1beta-induced NF-kappaB activity and it can also protect against IL-1beta-mediated apoptosis. Additionally, it is a ClipR-59 palmitoyltransferase that modifies the ClipR-59 plasma membrane binding and hence regulates the Akt signaling as well as Glut4 membrane translocation in adipocytes. It also facilitates the Mg2+ transport.

Séquence

Synthetic peptide located within the following region: LFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKP

Forme physique

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Wenying Ren et al.
Molecular and cellular biology, 33(21), 4255-4265 (2013-09-05)
ClipR-59 interacts with Akt and regulates Akt compartmentalization and Glut4 membrane trafficking in a plasma membrane association-dependent manner. The association of ClipR-59 with plasma membrane is mediated by ClipR-59 palmitoylation at Cys534 and Cys535. To understand the regulation of ClipR-59
Angela Goytain et al.
The Journal of biological chemistry, 283(48), 33365-33374 (2008-09-17)
Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. HIP14 protein has been shown to interact with huntingtin. HIP14 and a HIP14-like protein, HIP14L, with a 69% similarity reside in the Golgi and possess palmitoyl acyltransferase activity
Lukas Adrian Berchtold et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(37), E681-E688 (2011-06-28)
Type 1 diabetes (T1D) is a complex disease characterized by the loss of insulin-secreting β-cells. Although the disease has a strong genetic component, and several loci are known to increase T1D susceptibility risk, only few causal genes have currently been

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