A9522
Anti-Antithrombin III antibody produced in rabbit
fractionated antiserum, lyophilized powder
Synonyme(s) :
Anti-AT3
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
fractionated antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized powder
Espèces réactives
human
Conditionnement
vial of 2 mL lyophilized antiserum
Technique(s)
indirect ELISA: 1:25,000
Numéro d'accès UniProt
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... SERPINC1(462)
Catégories apparentées
Description générale
Antithrombin III (ATIII) is a small glycoprotein produced by the liver that functions as a serine protease inhibitor to block coagulation.
Antithrombin III is a 58kDa glycoprotein synthesized in the liver. It has two domains, a heparin-binding domain and target protease binding domain.
Immunogène
human antithrombin III
Application
Anti-Antithrombin III antibody has been used in western blotting and antigenic assay.
Actions biochimiques/physiologiques
Antithrombin III is a serine protease inhibitor which affects many intrinsic and extrinsic blood coagulation pathways. It inactivates the function of thrombin and factor X in blood. Severe sepsis is caused due to lack of antithrombin III.
Forme physique
Lyophilized from 0.01 M phosphate buffered saline, pH 7.2
Reconstitution
Reconstitute with 2 mL deionized water.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Eye Dam. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Defects of splicing in antithrombin deficiency
de la Morena-Barrio M E, et al.
Research and practice in thrombosis and haemostasis, 1(2), 216-222 (2017)
Mara Toderici et al.
PloS one, 11(3), e0152159-e0152159 (2016-03-24)
Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking regions of SERPINC1.We aimed to identify regulatory mutations inSERPINC1 through sequencing the
Antithrombin III in patients with severe sepsis
Eisele B, et al.
Intensive Care Medicine, 24(7), 663-672 (1998)
María Eugenia de la Morena-Barrio et al.
Frontiers in cardiovascular medicine, 9, 887664-887664 (2022-08-09)
Aortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern. To analyze the factors involved in the contact pathway during aortic valve replacement and to assess their impact
Carlos Bravo-Pérez et al.
JCI insight, 7(19) (2022-10-11)
Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We characterized the biological and clinical impact of variants involving C-terminal antithrombin. We performed comprehensive molecular, cellular, and clinical characterization of patients with C-terminal antithrombin variants from a cohort
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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