A7506

L-acide ascorbique

reagent grade, crystalline

• Synonyme(s) : Acide L-thréoascorbique, Facteur anti-scorbut, Vitamine C
• Formule empirique (notation de Hill): C₆H₈O₆
• Numéro CAS: 50-81-7
• Poids moléculaire : 176.12
• Numéro Beilstein : 84272
• Numéro CE : 200-066-2
• Numéro MDL: MFCD00064328
• Code UNSPSC : 12352209
• ID de substance PubChem : 24891246
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: synthetic
• Qualité: reagent grade
• Pureté: ≥98% ( with iodine, titration)
• Forme: crystalline
• Technique(s): HPLC: suitable; cell culture | stem cell: suitable
• Couleur: white to slightly yellow
• pH: 1.0-2.5 (25 °C, 176 g/L in water)
• Pf: 190-194 °C (dec.)
• Solubilité: water: soluble 50 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O
• InChI: 1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
• Clé InChI: CIWBSHSKHKDKBQ-JLAZNSOCSA-N
• Informations sur le gène: human ... SLC23A2(9962)

Description

Description générale

L-Ascorbic acid biosynthetic pathway varies in plants, animals and fungi. It is synthesized from L-gulono-1,4-lactone by the action of enzyme L-gulono-1,4-lactone oxidase (GLO).

Application

L-Ascorbic acid has been used:

• as a chondrogenic medium component for culturing bone-derived mesenchymal stem cells (BMSCs)(149)
• as a reference standard in high-performance liquid chromatography system (HPLC)(150)
• to test its effect on human gastric cancer GES-1 and AGS cells(151)

Actions biochimiques/physiologiques

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

L-Ascorbic acid deficiency is associated with lack of L-gulono-1,4-lactone oxidase (GLO) enzyme. It elicits antioxidant functionality and gets oxidized to dehydroascorbate via ascorbyl radical intermediate. L-Ascorbic acid is essential for maintaining the redox balance. It is a cofactor for dopamine-β-hydroxylase and favors T cell proliferation, protects immune system and provides relief in common cold.

Attention

May darken in storage.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)