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A7479

Sigma-Aldrich

5-AIQ hydrochloride

≥97% (HPLC), solid

Synonyme(s) :

5-Aminoisoquinolinone hydrochloride

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About This Item

Formule empirique (notation de Hill):
C9H9ClN2O
Numéro CAS:
93117-07-8
Poids moléculaire :
196.63
Numéro MDL:
MFCD03452659
Code UNSPSC :
12352202
ID de substance PubChem :
24724396
Nomenclature NACRES :
NA.77

Pureté

≥97% (HPLC)

Forme

solid

Couleur

tan

Solubilité

DMSO: >20 mg/mL
H2O: >20 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

Cl[H].Nc1cccc2C(=O)NC=Cc12

InChI

1S/C9H8N2O.ClH/c10-8-3-1-2-7-6(8)4-5-11-9(7)12;/h1-5H,10H2,(H,11,12);1H

Clé InChI

KWNLARCFSYAXLT-UHFFFAOYSA-N

Application

5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1). 5-AIQ hydrochloride was used in a study that determined PARP inhibitors have antiangiogenic effects, which may have tremendous clinical implications for the treatment of various cancers and certain retinopathies.

Actions biochimiques/physiologiques

5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1).

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Adrian C Nicolescu et al.
Biochemical and biophysical research communications, 387(4), 646-650 (2009-07-22)
Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidative stress associated with various pathologies. As MMP-2 plays a detrimental role in heart injuries resulting from enhanced nitroxidative
Mohanraj Rajesh et al.
Biochemical and biophysical research communications, 350(4), 1056-1062 (2006-10-19)
Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation. We
Ming Li et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 76(3), 108-116 (2009-05-27)
The current study was designed to test the hypothesis that inhibition of poly(ADP-ribose) polymerase in colorectal cancer mediates down-regulation of metastasis-related gene expression through the regulation of nuclear factor-kappaB (NF-kappaB) activity. Mouse colon carcinoma cells (CT26) were treated with and
Arnaud J Legrand et al.
PloS one, 8(2), e55883-e55883 (2013-02-14)
Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here, we identified poly(ADP-ribose) polymerase-1 (PARP-1) as a novel interaction
Yi Yuan et al.
Journal of tissue engineering and regenerative medicine, 13(9), 1499-1506 (2019-02-28)
Adipose tissues regenerated using tissue engineering chambers (TECs) show the potential for applications in reconstruction of soft tissue defects. Previous studies have shown that early inflammation plays a key role in angiogenesis and adipogenesis required for adipose tissue generation. However

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