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A7111

Sigma-Aldrich

Acepromazine maleate

≥98% (HPLC)

Synonyme(s) :

Acetopromazine maleate salt, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt

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About This Item

Formule empirique (notation de Hill):
C19H22N2OS · C4H4O4
Numéro CAS:
3598-37-6
Poids moléculaire :
442.53
Numéro CE :
222-748-9
Numéro MDL:
MFCD00082473
Code UNSPSC :
12352200
ID de substance PubChem :
329770915
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

protect from light

Couleur

yellow

Solubilité

H2O: >10 mg/mL

Température de stockage

room temp

Chaîne SMILES 

OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O

InChI

1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Clé InChI

FQRHOOHLUYHMGG-BTJKTKAUSA-N

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Application

Acepromazine maleate has been used:
  • as a component of anesthesia cocktail to test its effects on behavioral changes in rats
  • as a component of anesthesia cocktail to study its effects on lung resistance of rats
  • as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells

Actions biochimiques/physiologiques

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.

Caractéristiques et avantages

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H336

Conseils de prudence

P301 + P310 + P330

Classification des risques

Acute Tox. 3 Oral - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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The Japanese journal of veterinary research, 60(1), 5-13 (2012-03-31)
The metabolic mechanisms to circannual changes in body mass of bears have yet to be elucidated. We hypothesized that the Japanese black bear (Ursus thibetanus japonicus) has a metabolic mechanism that efficiently converts carbohydrates into body fat by altering insulin
Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis
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Effect of hypoxia-inducible factor-1/vascular endothelial growth factor signaling pathway on spinal cord injury in rats
Chen H, et al.
Experimental and Therapeutic Medicine, 13(3), 861-866 (2017)
Eleanor A Drynan et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 22(2), 262-266 (2012-04-11)
To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography. Retrospective clinical case study. University veterinary teaching hospital. Sixty-six dogs (mixed and pure breeds), aged between 4 months and
J M McGree et al.
Journal of veterinary pharmacology and therapeutics, 36(1), 31-42 (2013-01-16)
We describe the population pharmacokinetics of an acepromazine (ACP) metabolite (2-(1-hydroxyethyl)promazine) (HEPS) in horses for the estimation of likely detection times in plasma and urine. ACP (30 mg) was administered to 12 horses, and blood and urine samples were taken
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