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A273

Sigma-Aldrich

Monoclonal Anti-Na+/K+ ATPase (α3 Subunit) antibody produced in mouse

1 mg/mL, clone XVIF9-G10, ascites fluid

Synonyme(s) :

Anti-AHC2, Anti-ATP1A1, Anti-CAPOS, Anti-DEE99, Anti-DYT12, Anti-RDP

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About This Item

Numéro MDL:
MFCD01322380
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

XVIF9-G10, monoclonal

Poids mol.

antigen ~110 kDa

Espèces réactives

human, rat, monkey, sheep, rabbit, guinea pig, canine

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (frozen sections): 3 μg
western blot: 1 μg

Isotype

IgG1

Numéro d'accès UniProt

P13637

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ATP1A3(478)
rat ... Atp1a3(24213)

Description générale

Mouse monoclonal anti-Na+/K+ ATPase (α3 subunit) antibody reacts specifically with Na+/K+ ATPase α3 subunit. By immunoblotting, the product reacts with human, monkey, sheep, canine, rabbit, guinea pig and rat tissues in which the α3 subunit is expressed. Immunohistochemical staining is consistent with the plasma membrane localization of Na+/K+ ATPase.
Na+/K+ transporting ATPase subunit α1 is an ion transport pump critical for maintaining the gradient of Na and K ions across the plasma membrane.

Immunogène

canine cardiac microsomes.

Application

Mouse monoclonal anti-Na+/K+ ATPase (α3 subunit) antibody has been used for chemiluminescent western blot analysis. The product has also been used for co-immunoprecipitation applications.

Forme physique

Solution in phosphate buffered saline containing 0.05% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

S Basavappa et al.
Journal of cellular physiology, 174(2), 145-153 (1998-01-15)
The Na+ pump (Na+, K+-ATPase) has been implicated in the regulation of many cellular functions, including cell volume regulation. The effects of inhibiting Na+ pump activity on cell volume and taurine efflux were evaluated in the human neuroblastoma cell line
H Kawai et al.
Journal of neurochemistry, 69(1), 330-339 (1997-07-01)
Three isoforms of catalytic alpha subunits and two isoforms of beta subunits of Na+,K+-ATPase were detected in rat sciatic nerves by western blotting. Unlike the enzyme in brain, sciatic nerve Na+,K+-ATPase was highly resistant to ouabain. The ouabain-resistant alpha1 isoform
Katrina D Linning et al.
Pancreas, 29(3), e64-e76 (2004-09-16)
The limited availability of transplantable human islets has stimulated the development of methods needed to isolate adult pancreatic stem/progenitor cells capable of self-renewal and endocrine differentiation. The objective of this study was to determine whether modulation of intracellular redox state
R Zahler et al.
Circulation research, 78(5), 870-879 (1996-05-01)
The alpha (catalytic) subunit of the Na+ pump (Na+, K(+)-ATPase) has three isoforms; alpha1 is ubiquitous, skeletal muscle expresses predominantly alpha2, and alpha3 has been localized to specific types of neurons and, possibly, to axonal processes. The alpha3 isoform mRNA
Syed J Khundmiri et al.
American journal of physiology. Cell physiology, 291(6), C1247-C1257 (2006-06-30)
Cardiotonic glycosides, like ouabain, inhibit Na(+)-K(+)-ATPase. Recent evidence suggests that low molar concentrations of ouabain alter cell growth. Studies were conducted to examine the effect of ouabain on Akt phosphorylation and rate of cell proliferation in opossum kidney (OK) proximal
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