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Merck
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Principaux documents

A2487

Sigma-Aldrich

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

Synonyme(s) :

Trimethoprim-Sulfamethoxazole, TMP-SMX

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About This Item

Formule empirique (notation de Hill):
C14H18N4O3 · 5 C10H11N3O3S
Numéro CAS:
8064-90-2
Poids moléculaire :
1556.71
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.85

Forme

liquid

Niveau de qualité

200

Concentration

100 mg/mL in DMSO

Couleur

colorless to faint yellow

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites

Mode d’action

DNA synthesis | interferes

Conditions d'expédition

dry ice

Température de stockage

−20°C

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

Clé InChI

WZRJTRPJURQBRM-UHFFFAOYSA-N

Application

Cotrimoxazole has been used as an antimicrobial agent.

Actions biochimiques/physiologiques

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Conditionnement

1ml

Notes préparatoires

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H361fd,H412

Classification des risques

Aquatic Chronic 3 - Repr. 2

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
063M4068V
11130525

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Lise Denoeud-Ndam et al.
Journal of acquired immune deficiency syndromes (1999), 65(2), 198-206 (2013-11-14)
Malaria during pregnancy has serious consequences that are worsened by HIV infection. Malaria preventive measures for HIV-infected pregnant women include cotrimoxazole (CTX) prophylaxis given to prevent HIV-related opportunistic infections and also protective against malaria, or intermittent preventive treatment (IPTp) with
Osama M Sarhan et al.
Urology, 82(6), 1405-1409 (2013-10-22)
To evaluate the prognostic role of antenatal diagnosis of posterior urethral valves (PUVs) on ultimate renal function. Between 1990 and 2010, 315 patients with PUVs were diagnosed and treated at 2 separate tertiary centers. Primary valve ablation was performed in
H Abolhassani et al.
Journal of investigational allergology & clinical immunology, 23(5), 323-329 (2013-11-23)
Autoimmune disorders occur with a higher incidence in common variable immunodeficiency (CVID) patients than in the general population. To describe the clinical features of the autoimmune phenotype in patients with CVID. The hospital records of all diagnosed CVID patients referred
MMWR. Morbidity and mortality weekly report, 62(46), 914-916 (2013-11-22)
In March 2012, a Salvadoran-American boy aged 7 years living in Maryland developed three slightly painful, well-demarcated, flat, gray-brown patches on his torso. A dermatologist in Washington, DC, suspected a fixed drug eruption (an erythema multiforme-like adverse drug reaction that
Diversity of Escherichia coli strains producing extended-spectrum beta-lactamases in Spain: second nationwide study.
Diaz MA, et al.
Journal of Clinical Microbiology, 48, 2840-2845 (2010)
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