Accéder au contenu
Merck
Toutes les photos(2)

Key Documents

View All Documentation

A1757

Sigma-Aldrich

6-Azauracil

≥98%

Synonyme(s) :

6-AU, 1,2,4-Triazine-3,5(2H,4H)-dione, 3,5-Dihydroxy-1,2,4-triazine, 6-Aza-2,4-dihydroxypyrimidine

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Formule empirique (notation de Hill):
C3H3N3O2
Numéro CAS:
461-89-2
Poids moléculaire :
113.07
Numéro Beilstein :
116472
Numéro CE :
207-318-0
Numéro MDL:
MFCD00006456
Code UNSPSC :
41106305
ID de substance PubChem :
24890584
Nomenclature NACRES :
NA.51

Pureté

≥98%

Forme

powder

Pf

274-275 °C (lit.)

Solubilité

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green

Chaîne SMILES 

O=C1NN=CC(=O)N1

InChI

1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)

Clé InChI

SSPYSWLZOPCOLO-UHFFFAOYSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Application

6-Azauracil has been used as a transcriptional inhibitor to study its effects on the deletion of termination and polyadenylation protein (Tpa1) and Mag1 on cell viability. It has also been used as an orotidine-5′-monophosphate decarboxylase (OMPdecase) inhibitor in minimal media for determining the OMPdecase activity.

Actions biochimiques/physiologiques

6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP) and uridine triphosphate (UTP) nucleotide pools.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 3

1 of 3

Uridine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

U3003

Uridine

Fluconazole ≥98% (HPLC), powder

Sigma-Aldrich

F8929

Fluconazole

Streptomycin sulfate salt powder

Sigma-Aldrich

S6501

Streptomycin sulfate salt

Hai-Ning Du et al.
Genes & development, 22(20), 2786-2798 (2008-10-17)
Set2-mediated H3 K36 methylation is an important histone modification on chromatin during transcription elongation. Although Set2 associates with the phosphorylated C-terminal domain (CTD) of RNA polymerase II (RNAPII), the mechanism of Set2 binding to chromatin and subsequent exertion of its
Rahul V Nene et al.
PLoS genetics, 14(1), e1007170-e1007170 (2018-01-11)
Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with individual deletions of
Kazuko Matsubara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(1), 13-33 (2007-01-11)
The core histones are essential components of the nucleosome that act as global negative regulators of DNA-mediated reactions including transcription, DNA replication and DNA repair. Modified residues in the N-terminal tails are well characterized in transcription, but not in DNA
Peter L Freddolino et al.
eLife, 7 (2018-04-06)
Cells adapt to familiar changes in their environment by activating predefined regulatory programs that establish adaptive gene expression states. These hard-wired pathways, however, may be inadequate for adaptation to environments never encountered before. Here, we reveal evidence for an alternative
João Paulo Gobbo et al.
The journal of physical chemistry. B, 115(19), 6243-6251 (2011-04-21)
The nonadiabatic photochemistry of 6-azauracil has been studied by means of the CASPT2//CASSCF protocol and double-ζ plus polarization ANO basis sets. Minimum energy states, transition states, minimum energy paths, and surface intersections have been computed in order to obtain an
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique