A1260

Amantadine hydrochloride

≥98% (TLC), powder, NMDA receptor antagonist

• Synonyme(s) : 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride
• Formule empirique (notation de Hill): C₁₀H₁₇N · HCl
• Numéro CAS: 665-66-7
• Poids moléculaire : 187.71
• Numéro Beilstein : 4198854
• Numéro CE : 211-560-2
• Numéro MDL: MFCD00074723
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277882
• Nomenclature NACRES : NA.77

Propriétés

• product name: Amantadine hydrochloride,
• Forme: powder
• Solubilité: H₂O: 50 mg/mL; ethanol: soluble
• Auteur: Endo
• Chaîne SMILES: Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
• InChI: 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
• Clé InChI: WOLHOYHSEKDWQH-SOVZANNPSA-N

Description

Description générale

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Application

Amantadine hydrochloride has been used:

• to determine its effectiveness in reducing surgery-induced cognitive impairment
• to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
• to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
• to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
• to determine the pathway of internalization

Actions biochimiques/physiologiques

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves