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A0851

Sigma-Aldrich

Anti-Angiopoietin-2 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-Ang-2

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About This Item

Numéro MDL:
MFCD03096608
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

100

Produit recombinant

expressed in goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Poids mol.

antigen ~66 kDa

Espèces réactives

human

Technique(s)

ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL using human tissue
western blot: 0.1-0.2 μg/mL

Numéro d'accès UniProt

O15123

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ANGPT2(285)

Description générale

Angiopoietin 2 is an endothelial cell-specific protein and has a pivotal role in mature blood vessel formation, endothelial cell proliferation and embryogenic angiogenesis. Angiopoietin 2 produced by endothelial cells of interior tumor vessels, stimulates vessel regression and disassociation from surrounding tumor cells. Anti-angiopoietin-2 antibody can be used in western blotting. Goat anti-angiopoietin-2 antibody reacts specifically with recombinant human angiopoietin-2. The product may also show 25% (approx.) cross-reactivity for recombinant human angiopoietin-1.

Immunogène

purified recombinant human angiopoietin-2 expressed in mouse NSO cells.

Application

Anti-angiopoietin-2 antibody can be used in immunohistochemistry for detecting humanangiopoietin-2 using paraffin-embedded human tissue sections. It can also be used in ELISA.
Goat anti-angiopoietin-2 antibody is also suitable for use in western blot assays at 0.1-0.2 μg/mL

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (pH 7.4) with 5% trehalose

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jawun Choi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 117, 109091-109091 (2019-06-23)
Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs. Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors. However, it is still unclear whether diosmetin exerts anti-cancer effects, particularly anti-angiogenic effects
Shigetomo Fukuhara et al.
Histology and histopathology, 25(3), 387-396 (2010-01-08)
Angiopoietin (Ang) 1 is a ligand for endothelium-specific receptor tyrosine kinase Tie-2. In adult vasculature, Ang1/Tie2 signaling is thought to regulate both maintenance of vascular quiescence and promotion of angiogenesis. However, it has been unknown how Tie2 signal regulates these
Changqing Luo et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(3), 916-928 (2014-09-10)
To investigate the role of angiopoietin-2 (Ang-2) and IL-18 in the pathogenesis of diabetic nephropathy (DN) and the molecular mechanisms through which alprostadil protects renal function. DN was induced by streptozotocin and intraperitoneal injection of alprostadil was given to diabetic
Z Zhou et al.
Cell death and differentiation, 22(3), 488-498 (2015-01-13)
Damage and loss of the postmitotic photoreceptors is a leading cause of blindness in many diseases of the eye. Although the mechanisms of photoreceptor death have been extensively studied, few studies have addressed mechanisms that help sustain these non-replicating neurons

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