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Key Documents

67578

Sigma-Aldrich

Sulfate de dextrane sodium salt

Synonyme(s) :

Dextran Sulfate Sodium

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About This Item

Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25

Forme

powder

Niveau de qualité

200

Perte

≤10% loss on drying

Plage de pH utile

6.0-8.0 (10 g/L)

Solubilité

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

Température de stockage

room temp

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Description générale

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
Dextran sulfate is used as a diluent in in situ hybridization experiments to increase hybridization of probes to target sequences in tissues.

Autres remarques

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

The rate of nucleic acid annealing to cytological preparations is increased in the presence of dextran sulfate.
L L Lederman et al.
Analytical biochemistry, 117(1), 158-163 (1981-10-01)
Rodabe N Amaria et al.
Nature medicine, 24(11), 1649-1654 (2018-10-10)
Preclinical studies suggest that treatment with neoadjuvant immune checkpoint blockade is associated with enhanced survival and antigen-specific T cell responses compared with adjuvant treatment1; however, optimal regimens have not been defined. Here we report results from a randomized phase 2
Nadezhda V Petrova et al.
Cell cycle (Georgetown, Tex.), 15(3), 337-344 (2015-12-23)
Heat stress is one of the best-studied exogenous stress factors; however little is known about its delayed effects. Recently, we have shown that heat stress induces cellular senescence-like G2 arrest exclusively in early S-phase cells. The mechanism of this arrest
Sinah-Sophia Weiterer et al.
The EMBO journal, 39(1), e101533-e101533 (2019-11-09)
How cytokine-driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)-1α induces acute and widespread changes in chromatin accessibility via the TAK1 kinase and NF-κB at regions that
Adél Sepsi et al.
Frontiers in plant science, 9, 1193-1193 (2018-08-30)
ImmunoFISH is a method combining immunolabelling (IL) with fluorescent in situ hybridisation (FISH) to simultaneously detect the nuclear distribution of proteins and specific DNA sequences within chromosomes. This approach is particularly important when analysing meiotic cell division where morphogenesis of

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