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Merck
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Principaux documents

483R-1

Sigma-Aldrich

p40 (ZR8) Rabbit Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

ZR8

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (483R-14)
vial of 0.1 mL concentrate, Research Use Only (483R-14-RUO)
vial of 0.5 mL concentrate (483R-15)
vial of 1.0 mL concentrate (483R-16)
vial of 1.0 mL concentrate, Research Use Only (483R-16-RUO)
vial of 1.0 mL pre-dilute, Research Use Only (483R-17-RUO)
vial of 1.0 mL pre-dilute, ready to use (483R-17)
vial of 25.0 mL pre-dilute, ready-to-use (483R-10)
vial of 25.0 mL pre-dilute, ready-to-use, Research Use Only (483R-10-RUO)
vial of 7.0 mL pre-dilute, ready to use (483R-18)
vial of 7.0 mL pre-dilute, ready to use, Research Use Only (483R-18-RUO)

Fabricant/nom de marque

Cell Marque

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

Isotype

IgG

Contrôle

lung (squamous cell carcinoma), prostate, urothelial carcinoma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Catégories apparentées

Description générale

p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland.1-5 Strong p40 expression is frequently observed in esophageal cancerous squamous lesions.6 Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma.7 In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining.8

Qualité

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

Download the IFU specific to your product lot and format
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Autres remarques

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Hermann Brustmann
Pathology research international, 2015, 897927-897927 (2015-04-09)
Immunohistochemistry is important for the accurate diagnosis of basal cells in atypical glandular proliferations of the prostate. p40, an isoform of p63, may be an adjunct to a marker panel in this setting. Biopsies of 68 patients were analyzed by
Khairunisa Ahmad Affandi et al.
Journal of pathology and translational medicine, 52(5), 283-289 (2018-09-22)
Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become
Helene Geddert et al.
Human pathology, 34(9), 850-856 (2003-10-17)
p63, a member of the p53 gene family, is known to encode functionally antagonistic protein isoforms. Although transactivating protein isoforms display p53-like functions, deltaNp63 isoforms act toward p53 in a dominant negative way. Using immunohistochemistry, we examined the expression of
Ritika Walia et al.
The Indian journal of medical research, 146(1), 42-48 (2017-11-24)
Accurate histopathological subtyping of non-small cell lung carcinoma (NSCLC) is essential for targeted therapeutic agents. Immunohistochemistry (IHC) is helpful in identification of different tumour subtypes. In this study two marker approaches, one each for glandular and squamous cell differentiation was

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