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Merck
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Key Documents

44213

Sigma-Aldrich

Thromboplastin from rabbit

Synonyme(s) :

Thromboplastin, Factor III, Thrombokinase

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About This Item

Numéro CAS:
72162-96-0
Numéro CE :
276-433-6
Numéro MDL:
MFCD00148638
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.25

Source biologique

rabbit

Niveau de qualité

100

Forme

lyophilized solid

Numéro d'accès UniProt

P24055

Température de stockage

2-8°C

Informations sur le gène

rabbit ... F3(100009127)

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Application

Thromboplastin from rabbit has been used:
  • as a standard in tissue factor procoagulant activity assay (TF-PCA)
  • in pulmonary embolism assay
  • as a positive control in clotting assay using human plasma

Actions biochimiques/physiologiques

Thromboplastin (Tissue factor) is a transmembrane protein, the chief in vivo activator of blood coagulation that leads to thrombin generation and fibrin deposition. It is also important in the activation of the coagulation protease cascade and is involved in the lethality of sepsis.,
Thromboplastin from rabbit might be used to produce disseminated intravascular coagulation (DIC) in animal models.

Conditionnement

One vial contains 3-4 mg thromboplastin.

Reconstitution

Reconstitute the content of 1 vial in 4 ml 10 mm CaCl2

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H334

Conseils de prudence

P261 - P284 - P501

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

M E Bromberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8205-8209 (1995-08-29)
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis. In the study reported here, a murine model of human melanoma
J Erlich et al.
Infection and immunity, 67(5), 2540-2546 (1999-05-04)
Tissue factor (TF) is the major activator of the coagulation protease cascade and contributes to lethality in sepsis. Despite several studies analyzing TF expression in animal models of endotoxemia, there remains debate about the cell types that are induced to
Nan Zhang et al.
The Journal of experimental medicine, 216(6), 1291-1300 (2019-05-03)
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in
Richard Beatson et al.
Communications biology, 3(1), 644-644 (2020-11-06)
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, phenotypic, functional and geographical diversity. Here

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