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Y0001182

Captopril for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Captopril, N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline

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About This Item

Formule empirique (notation de Hill):
C9H15NO3S
Numéro CAS:
62571-86-2
Poids moléculaire :
217.29
Numéro Beilstein :
477887
Numéro MDL:
MFCD00168073
Code UNSPSC :
41116107
ID de substance PubChem :
329831295
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

captopril

Fabricant/nom de marque

EDQM

Pf

104-108 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

Clé InChI

FAKRSMQSSFJEIM-RQJHMYQMSA-N

Informations sur le gène

human ... ACE(1636)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Captopril for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1091200

Captopril, United States Pharmacopeia (USP) Reference Standard

1091221

Captopril disulfide, United States Pharmacopeia (USP) Reference Standard

PHR1307

Captopril, Pharmaceutical Secondary Standard; Certified Reference Material

C0430000

Captopril, European Pharmacopoeia (EP) Reference Standard

Y0000435

Captopril impurity E, European Pharmacopoeia (EP) Reference Standard

Y0001221

Captopril impurity D, European Pharmacopoeia (EP) Reference Standard

Y0001219

Captopril impurity B, European Pharmacopoeia (EP) Reference Standard

Y0001220

Captopril impurity C, European Pharmacopoeia (EP) Reference Standard

Y0001450

Captopril impurity J, European Pharmacopoeia (EP) Reference Standard

BP538

Captopril, British Pharmacopoeia (BP) Reference Standard

BP500

Captopril disulfide, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H341,H360F

Conseils de prudence

P201 - P308 + P313

Classification des risques

Muta. 2 - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Samir Attoub et al.
Annals of the New York Academy of Sciences, 1138, 65-72 (2008-10-08)
Lung cancer is the most common form of cancer in the world, and 90% of patients die from their disease. The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease
Johannes J Kovarik et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(1), 115-123 (2014-08-12)
Blockade of the renin-angiotensin system (RAS) exerts beneficial effects in patients with mild-to-moderate chronic kidney disease, yet evidence suggesting a similar benefit in haemodialysis (HD) patients is not available. Furthermore, knowledge of the effects of RAS blockade on systemic RAS
Marie-Claude Racine et al.
Current hypertension reports, 4(3), 245-249 (2002-05-11)
With the introduction of more simple screening tests such as the aldosterone/renin ratio, the detection rate of primary aldosteronism has increased considerably. Until now, no reference values have been available for reporting the aldosterone/renin ratio using plasma aldosterone values expressed
A Schattner et al.
The American journal of the medical sciences, 322(4), 236-240 (2001-10-27)
Two elderly patients, treated with captopril for left ventricular dysfunction and diabetes, developed severe cholestatic jaundice for which no alternative explanation could be found. The jaundice resolved completely after discontinuation of the drug. A review of the literature identifies a
A O Nur et al.
International journal of pharmaceutics, 194(2), 139-146 (2000-02-29)
The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered with such topic based on the fact that the drug is freely water
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