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Y0000155

Tramadol hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(±)-cis-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol hydrochloride

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About This Item

Formule empirique (notation de Hill):
C16H25NO2 · HCl
Numéro CAS:
36282-47-0
Poids moléculaire :
299.84
Numéro MDL:
MFCD00798507
Code UNSPSC :
41116107
ID de substance PubChem :
329830868
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

tramadol

Fabricant/nom de marque

EDQM

Contrôle du médicament

USDEA Schedule IV

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C

InChI

1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1

Clé InChI

PPKXEPBICJTCRU-XMZRARIVSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Tramadol is a synthetic opiate agonist analgesic, widely used in patients suffering from moderate to severe chronic pain. It is considered safe when compared to other opioids. It contributes to the analgesic activity by blocking the nociceptive impulses at the spinal level, inhibiting the norepinephrine and serotonin reuptake.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Opioid analgesic; P450 substrate.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H336,H411

Classification des risques

Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Analgesic oral efficacy of tramadol hydrochloride in postoperative pain
Sunshine A, et al.
Clinical Pharmacology and Therapeutics, 51(6), 740-746 (1992)
Application of HPLC for the simultaneous determination of aceclofenac, paracetamol and tramadol hydrochloride in pharmaceutical dosage form
Chandra P, et al.
Scientia Pharmaceutica, 80(2), 337-352 (2012)
Emrah Yuruk et al.
Journal of endourology, 29(4), 463-467 (2014-10-01)
To compare the outcomes of these minimally invasive procedures in this patient population. The database of our institution has been retrospectively reviewed, and medical records of urolithiasis patients with a solitary kidney who underwent flexible ureteroscopy (F-URS) or extracorporeal shock
Guojun Wu et al.
International journal of clinical and experimental pathology, 7(9), 5665-5673 (2014-10-23)
This study is to establish the rhesus monkey model of lymphedema in the upper limbs, and assess the suitability of this model. An animal model of lymphedema was established by the combined irradiation and surgical techniques in the upper limbs
Marco Cespi et al.
International journal of pharmaceutics, 477(1-2), 140-147 (2014-10-12)
The use of process analytical technologies (PAT) to ensure final product quality is by now a well established practice in pharmaceutical industry. To date, most of the efforts in this field have focused on development of analytical methods using spectroscopic
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