SMB01335

N¹-Acetyl-N²-formyl-5-methoxykynuramine

≥95% (HPLC)

• Synonyme(s) : AFMK, AFMKA, NSC-688263, NSC688263, N-[3-[2-(Formylamino)-5-methoxyphenyl]-3-oxopropyl]acetamide, NSC 688263
• Formule empirique (notation de Hill): C₁₃H₁₆N₂O₄
• Numéro CAS: 52450-38-1
• Poids moléculaire : 264.28
• Numéro MDL: MFCD02683241
• Code UNSPSC : 12352116
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥95% (HPLC)
• Forme: solid
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc(NC=O)c(c1)C(=O)CCNC(C)=O
• InChI: 1S/C13H16N2O4/c1-9(17)14-6-5-13(18)11-7-10(19-2)3-4-12(11)15-8-16/h3-4,7-8H,5-6H2,1-2H3,(H,14,17)(H,15,16)
• Clé InChI: JYWNYMJKURVPFH-UHFFFAOYSA-N

Description

Description générale

Melatonin and its metabolites are being studied for their antioxidant properties and their protective effects against oxidative stress in both mammals and in plants. N¹-Acetyl-5-methoxykynuramine (AMK) and its direct precursor N¹-acetyl-N²-formyl-5-methoxykynuramine (AFMK) are two metabolites that contribute to the antioxidant properties of melatonin.

Application

Metabolomics research

Actions biochimiques/physiologiques

AFMK is a melatonin metabolite first detected in rat brain; demonstrates antioxidant and free radical scavenging activities in several experimental models; inhibits LPS-mediated production of TNFα and IL-8 in neutrophils; useful tool in the study of melatonin metabolism.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable