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Key Documents

PHR1303

Supelco

3,4,4` Trichlorocarbanilide (Triclocarban)

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

3,4,4′-Trichlorocarbanilide, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea, TCC, Triclocarban

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About This Item

Formule linéaire :
Cl2C6H3NHCONHC6H4Cl
Numéro CAS:
Poids moléculaire :
315.58
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

Pression de vapeur

<0.1 mmHg ( 25 °C)

Famille d'API

triclocarban

CofA (certificat d'analyse)

current certificate can be downloaded

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

254-256 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-30°C

Chaîne SMILES 

Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1

InChI

1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)

Clé InChI

ICUTUKXCWQYESQ-UHFFFAOYSA-N

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Description générale

3,4,4′-Trichlorocarbanilide (Triclocarban) is an ester of 3,4,4′-trichlorocarbanilide and belongs to the group of endocrine disruptors. It is widely used as a preservative and bactericide in a variety of personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAA0063 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogrammes

Environment

Mention d'avertissement

Warning

Mentions de danger

Conseils de prudence

Classification des risques

Aquatic Acute 1 - Aquatic Chronic 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

>302.0 °F

Point d'éclair (°C)

> 150 °C


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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry
Gonzalez-Marino I, et al.
Rapid Communications in Mass Spectrometry, 23(12), 1756-1766 (2009)
Jian-Liang Zhao et al.
Water research, 47(1), 395-405 (2012-11-07)
Triclosan (TCS) and triclocarban (TCC) are two commonly used personal care products. They may enter into aquatic environments after consumption and pose potential risks to aquatic organisms. We investigated the occurrence and fate of TCS and TCC in five large
Nils Helge Schebb et al.
Aquatic toxicology (Amsterdam, Netherlands), 105(3-4), 448-454 (2011-08-30)
The antimicrobial triclocarban (TCC) is frequently found in personal care products and commonly observed in surface waters and sediments. Due to its long environmental persistence TCC accumulates in sewage sludge. It also shows a high unintended biological activity as a
Niroj Aryal et al.
Water research, 45(17), 5545-5552 (2011-09-10)
Triclocarban and triclosan, two antimicrobials widely used in consumer products, can adversely affect ecosystems and potentially impact human health. The application of biosolids to agricultural fields introduces triclocarban and triclosan to soil and water resources. This research examined the phytoaccumulation
Arjun K Venkatesan et al.
Journal of hazardous materials, 229-230, 29-35 (2012-06-30)
The antimicrobial agents triclosan (TCS), triclocarban (TCC) and their associated transformation products are of increasing concern as environmental pollutants due to their potential adverse effects on humans and wildlife, including bioaccumulation and endocrine-disrupting activity. Analysis by tandem mass spectrometry of

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