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N0020000

Nabumetone

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4-(6-Methoxy-2-naphthyl)-2-butanone

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About This Item

Formule empirique (notation de Hill):
C15H16O2
Numéro CAS:
42924-53-8
Poids moléculaire :
228.29
Numéro MDL:
MFCD00079518
Code UNSPSC :
41116107
ID de substance PubChem :
329818390
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

nabumetone

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

COc1ccc2cc(CCC(C)=O)ccc2c1

InChI

1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

Clé InChI

BLXXJMDCKKHMKV-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS2(5743)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nabumetone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Nonselective non-steroidal anti-inflammatory drug (NSAID)

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

N0020020

Nabumetone impurity D, European Pharmacopoeia (EP) Reference Standard

N0020030

Nabumetone impurity F, European Pharmacopoeia (EP) Reference Standard

1449518

Nabumetone, United States Pharmacopeia (USP) Reference Standard

1449530

Nabumetone Related Compound A, United States Pharmacopeia (USP) Reference Standard

08137

2-(6-Methoxynaphthalen-2-yl)acetic acid, pharmaceutical impurity standard

BP358

Nabumetone, British Pharmacopoeia (BP) Reference Standard

BP851

Nabumetone impurity D, British Pharmacopoeia (BP) Reference Standard

PHR3056

Nabumetone, pharmaceutical secondary standard, certified reference material

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Consulter la Bibliothèque de documents

R Andrew Moore et al.
The Cochrane database of systematic reviews, (4)(4), CD007548-CD007548 (2009-10-13)
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used mainly in treating pain associated with arthritis. The usual oral dose for osteoarthritis is 1000 mg daily, and higher doses are not advised in older patients. There are no known systematic reviews
Neha Sethi et al.
Journal of chromatographic science, 50(2), 85-90 (2012-02-03)
High efficiency and less run time are the basic requirements of high-speed chromatographic separations. To fulfill these requirements, a new separation technique, ultra-performance liquid chromatography (UPLC), has shown promising developments. A rapid, specific, sensitive, and precise reverse-phase UPLC method is
Lenka Nespesná et al.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 60(1), 17-24 (2011-06-10)
The study aimed to establish and validate an analytical method for the determination of nabumetone and 6-methoxy-2-naphthylacetic acid (6-MNA) in human plasma after a single therapeutic dose of the drug. Two methods based on HPLC with UV and MS detection
David Foley et al.
Organic & biomolecular chemistry, 7(6), 1064-1067 (2009-03-06)
Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro.
Solubility of triamcinolone acetonide and other anti-inflammatory drugs in silicone oil: implications for Therapeutic Efficacy.
José Carlos Pastor et al.
Retina (Philadelphia, Pa.), 28(9), 1247-1250 (2008-07-17)
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