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89640

Sigma-Aldrich

Toluidine Blue

8.74% (ZN (THEORY)), for microscopy (Hist., Vit.)

Synonyme(s) :

Tolonium chloride; Basic Blue 17

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About This Item

Formule empirique (notation de Hill):
C15H16ClN3S · 0.5ZnCl2
Numéro CAS:
6586-04-5
Poids moléculaire :
373.97
Numéro C.I. (Colour Index):
52040
Numéro Beilstein :
4068052
Numéro MDL:
MFCD03548293
Code UNSPSC :
12171500
ID de substance PubChem :
329769757
Nomenclature NACRES :
MA.02

Qualité

for microscopy (Hist., Vit.)

Niveau de qualité

200

Pureté

8.74% (ZN (THEORY))

Forme

powder or crystals

Couleur

green to very dark green

Solubilité

methanol: 0.01 g/10 mL, blue to very deep blue

εmax

≥800 at 621-636 nm in water

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

[Cl-].[Cl-].Cl[Zn]Cl.Cc1cc2N=C3C=CC(\C=C3Sc2cc1N)=[N+](\C)C.Cc4cc5N=C6C=CC(\C=C6Sc5cc4N)=[N+](\C)C

InChI

1S/2C15H15N3S.4ClH.Zn/c2*1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;;;;;/h2*4-8,16H,1-3H3;4*1H;/q;;;;;;+2/p-2

Clé InChI

DAQXTSXITPUGRG-UHFFFAOYSA-L

Description générale

Toluidine blue (C.l. 52040) is a diaminothiazine dye.It is also known as TBO, tolonium chloride, and toluidine blue O.

Application

Toluidine Blue is suitable for use in the following applications:
  1. to demonstrate amyloid; DNA in plant material, mast cells, Nissl substance, nuclei, and sulfatides
  2. in metachromatic staining of sulfated mucins and related materials
  3. as staining agent to identify the development and accumulation of the cartilage matrix, proteoglycans for isolation and culture of mesenchymal stem cells from mouse compact bone.
  4. staining of mucins in water-miscible resins and of nucleic acids in epoxy resins(1)

Actions biochimiques/physiologiques

Toluidine Blue is a basic thiazine metachromatic dye, which is used for selectively staining acidic tissue components such as carboxylates, sulfates, and phosphate radicals.It is found to have an affinity for nucleic acids and therefore binds to the nuclear material of tissues with a high DNA and RNA content.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCH1582
BCCD9721
BCBZ9485
BCBW2861
BCBW0650

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Consulter la Bibliothèque de documents

Yonggang Lu et al.
PloS one, 12(4), e0174907-e0174907 (2017-04-04)
For the first time, this study has systemically investigated the male reproductive system in a sessile broadcast-spawning marine invertebrate, Galeolaria caespitosa (Polychaeta: Serpulidae), which has significant potential as a bio-indicator species of coastal marine pollution. The abdomen of G. caespitosa
Toluidine blue: A review of its chemistry and clinical utility.
Sridharan G and Shankar AA
International Journal of Oral and Maxillofacial Pathology, 16(2), 251-255 (2012)
Xiaoli Guo et al.
PLoS pathogens, 13(2), e1006142-e1006142 (2017-02-06)
Stem cell pools in the SAM (shoot apical meristem), RAM (root apical meristem) and vascular procambium/cambium are regulated by CLE-receptor kinase-WOX signaling modules. Previous data showed that cyst nematode CLE-like effector proteins delivered into host cells through a stylet, act
Yu Han et al.
International journal of molecular sciences, 20(14) (2019-07-25)
Rosa chinensis is one of the most popular flower plants worldwide. The recurrent flowering trait greatly enhances the ornamental value of roses, and is the result of the constant formation of new flower buds. Flower bud differentiation has always been
A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone.
Zhu H, et al.
Nature Protocols, 5, 550-560 (2010)
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