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73658

Supelco

Ginsenoside Rh2

analytical standard

Synonyme(s) :

(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside, 20(S)-Ginsenoside-Rh2

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About This Item

Formule empirique (notation de Hill) :
C36H62O8
Numéro CAS:
78214-33-2
Poids moléculaire :
622.87
Numéro MDL:
MFCD00800712
Code UNSPSC :
85151701
ID de substance PubChem :
329765120
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Essai

≥97.0% (HPLC)

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

food and beverages

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C\C(C)=C/CC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)(C)[C@@H]4CC[C@@]23C

InChI

1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1

Clé InChI

CKUVNOCSBYYHIS-IRFFNABBSA-N

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Description générale

Ginsenoside Rh2 is an active component of Red P. ginseng. It is reported to be obtained as a metabolite of ginsenoside Rg3, when anaerobically incubated with human fecal microflora.

Application

Ginsenoside Rh2 may be used as an analytical reference standard for the quantification of the analyte in plasma samples using high-performance liquid chromatography technique.[24]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Autres remarques

This compound is commonly found in plants of the genus: panax

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
BCCH1115
BCCG0514
BCBV9500
BCCB2967
BCBT0133

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Y Gu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 40(9), 602-612 (2010-07-09)
This study investigated the absorption mechanism of ginsenoside Rh2 to clarify the reasons for its poor absorption. Transepithelial transport across Caco-2 cell monolayers, cellular uptake, and in situ rat intestinal perfusion were examined. Cellular uptake of Rh2 was linear from
Bei Zhou et al.
Talanta, 88, 345-351 (2012-01-24)
The quartz crystal microbalance (QCM) dynamic measurements indicate that ginsenoside Rh(2) (G-Rh(2)) could inhibit the proliferation of adriamycin-resistant human breast cancer MCF-7 cells (MCF-7/ADR) in a concentration-dependent way. The combined treatment of G-Rh(2) with adriamycin (ADR) at non-effect dosage resulted
Liang Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 2041-2053 (2012-07-26)
20(S)-Ginsenoside Rh2 (Rh2)-containing products are widely used in Asia, Europe, and North America. However, extremely limited metabolism information greatly impedes the complete understanding of its clinical safety and effectiveness. The present study aims to systematically investigate the oxidative metabolism of
Long He et al.
Bone, 50(6), 1207-1213 (2012-04-10)
Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present
Kyung-Sook Chung et al.
Carcinogenesis, 34(2), 331-340 (2012-11-06)
The triterpene saponin ginsenoside Rh2 has been shown to have antiproliferative effects on various cancer cells. However, the effect of Rh2 on the cell cycle and its underlying molecular mechanism in human leukemia cells are not fully understood. In this
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