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Spermidine

analytical standard

Synonyme(s) :

1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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About This Item

Formule linéaire :
NH2(CH2)3NH(CH2)4NH2
Numéro CAS:
124-20-9
Poids moléculaire :
145.25
Numéro Beilstein :
1698591
Numéro CE :
204-689-0
Numéro MDL:
MFCD00008229
Code UNSPSC :
85151701
ID de substance PubChem :
329757521

Qualité

analytical standard

Niveau de qualité

100

Pureté

≥97.5% (NT)
≥99.0% (GC)

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.479 (lit.)

Densité

0.925 g/mL at 25 °C (lit.)

Application(s)

cleaning products
cosmetics
food and beverages
personal care

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

Clé InChI

ATHGHQPFGPMSJY-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Spermidine is a naturally occurring polyamine compound commonly found in food. It is essential for cell growth and survival.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Spermidine may be used as one of the reference standard for the determination of spermidine in biological samples by high performance liquid chromatography-electrospray ionization–ion trap tandem mass spectrometry (HPLC–ESI–ITMS/MS).

Actions biochimiques/physiologiques

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Attention

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H314

Classification des risques

Eye Dam. 1 - Skin Corr. 1B

Code de la classe de stockage

8A - Combustible, corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

233.6 °F - closed cup

Point d'éclair (°C)

112 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number
BCCG3819
BCCF5855
BCCD8632
BCCD2772
BCCB7355

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Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography?electrospray ionization?ion trap tandem mass spectrometry (HPLC?ESI?ITMS/MS).
Ibarra A A G, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1002, 176-184 (2015)
Micro-scale strategy to detect spermine and spermidine by MALDI?TOF MS in foods and identification of apoptosis-related proteins by nano-flow UPLC?MS/MS after treatment with spermine and spermidine
Su H H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 978, 131-137 (2015)
Varun K Gupta et al.
Nature neuroscience, 16(10), 1453-1460 (2013-09-03)
Age-dependent memory impairment is known to occur in several organisms, including Drosophila, mouse and human. However, the fundamental cellular mechanisms that underlie these impairments are still poorly understood, effectively hampering the development of pharmacological strategies to treat the condition. Polyamines
Eugenia Morselli et al.
Aging, 1(12), 961-970 (2010-02-17)
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced by our groups demonstrates that
Andrew Breakspear et al.
The Plant cell, 26(12), 4680-4701 (2014-12-21)
Nitrogen-fixing rhizobia colonize legume roots via plant-made intracellular infection threads. Genetics has identified some genes involved but has not provided sufficient detail to understand requirements for infection thread development. Therefore, we transcriptionally profiled Medicago truncatula root hairs prior to and
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