43107

Vitamine B₁₂

tested according to Ph. Eur.

• Synonyme(s) : α-(5,6-Diméthylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamine, Cyanocobalamine
• Formule empirique (notation de Hill): C₆₃H₈₈CoN₁₄O₁₄P
• Numéro CAS: 68-19-9
• Poids moléculaire : 1355.37
• Numéro Beilstein : 4122889
• Numéro CE : 200-680-0
• Code UNSPSC : 12352200
• ID de substance PubChem : 329756307
• Nomenclature NACRES : NA.21

Propriétés

• Source biologique: fermentation/recombinant
• Niveau de qualité: 100
• Agence: USP/NF; tested according to Ph. Eur.
• Pureté: 96.0-102.0% dry basis
• Forme: powder
• Couleur: dark red
• Solubilité: water: soluble 1 gm in 80 ml; acetone: insoluble; alcohol: soluble; chloroform: insoluble; diethyl ether: insoluble
• Application(s): cell analysis
• Température de stockage: 2-8°C
• Chaîne SMILES: C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@
• InChI: 1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1
• Clé InChI: RMRCNWBMXRMIRW-QJRSUKKJSA-L

Description

Description générale

Cyanocobalamin, also referred to as Vitamin B₁₂, is a water soluble vitamin.

Application

Cyanocobalamin was added in the assay buffer during the analysis step of ELISA for ensuring that all transcobalamin was saturated with cobalamin before analysis. Cyanocobalamin was also used for examining its impact on the expression of mPer1 and mPer2 in vivo.

Actions biochimiques/physiologiques

Cyanocobalamin plays a role in functioning of brain and nervous system. It is also involved in hematopoiesis. Vitamin B₁₂ deficiency leads to megaloblastic anemia. It is also associated with irreversible nervous system breakdown leading to spinal cord degeneration.

Cyanocobalamin refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. Cyanocobalamin along with other B vitamins thiamine (B1) and pyridoxine (B6) blocks the thermal hyperalgesia in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ligation of the sciatic nerve (CCI). It can stimulate the anaerobic biodegradation of chloroform.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)