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Documents

SCC069

HSC-T6 Rat Hepatic Stellate Cell Line

Name: HSC-T6 Rat Hepatic Stellate Cell Line
Brand: MM

Rat

Synonyme(s) :

HSC, Perisinusoidal cells, Ito cells, Hepatic lipocytes, Hepatic pericytes

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About This Item

Code UNSPSC :

41106514

eCl@ss :

32011203

Nomenclature NACRES :

NA.81

product name

HSC-T6 Rat Hepatic Stellate Cell Line, The HSC-T6 rat hepatic stellate cell line is a valuable cell model for studies of retinoid metabolism based on their similar retinoid phenotype as primary cells.

Source biologique

rat

Niveau de qualité

100

Technique(s)

cell based assay: suitable
cell culture | mammalian: suitable

Conditions d'expédition

ambient

Catégories apparentées

Culture cellulaire et analyse de cultures cellulaires

Lignées cellulaires et culture cellulaire spécialisée

Lignées de cellules de mammifères

Description générale

Hepatocytes and hepatic stellate cells play important roles in retinoid uptake, storage, mobilization and metabolism. Hepatic stellate cells represent only 5-7% of the total cells present in the liver. Isolation of primary stellate cells is thus time-consuming and often accompanied by low yields and considerable lot-to-lot variations. HSC-T6 Rat Hepatic Stellate Cell Line is an immortalized line isolated from SV40 large T-antigen transformed primary stellate cells of male Sprague-Dawley retired breeder rats. HSC-T6 Rat Hepatic Stellate Cell line is a useful model for the study of hepatic retinoid storage and metabolism.

Description de la lignée cellulaire

Hepatocyte Cells

Application

Research Category
Metabolism

Infectious Diseases

Inflammation & Immunology

Stem Cell Research

Research Sub Category
Liver Physiology

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Composants

1) ≥1X10⁶ viable HSC-T6 Rat Hepatic Stellate Cells: (Catalog No. SCC069). Store in liquid nitrogen.

Qualité

• Each vial contains ≥ 1X10⁶ viable cells.
• Cells tested negative for infectious diseases by a Mouse/Rat Comprehensive CLEAR panel PCR panel by Charles River Animal Diagnostic Services.
• Cells tested negative for mycoplasma contamination.

Stockage et stabilité

HSC-T6 Rat Hepatic Stellate Cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats.

Ryuichi Noguchi et al.

Molecular medicine reports, 22(4), 2948-2956 (2020-09-19)

An orally bioavailable small molecule inhibitor of plasminogen activator inhibitor‑1 (PAI‑1) is currently being clinically assessed as a novel antithrombotic agent. Although PAI‑1 is known to serve a key role in the pathogenesis of metabolic syndrome (MetS) including nonalcoholic steatohepatitis

Chrysophanol Prevents Lipopolysaccharide-Induced Hepatic Stellate Cell Activation by Upregulating Apoptosis, Oxidative Stress, and the Unfolded Protein Response.

Jiunn-Sheng Wu et al.

Evidence-based complementary and alternative medicine : eCAM, 2020, 8426051-8426051 (2020-07-28)

Hepatic stellate cell (HSC) activation is a vital driver of liver fibrosis. Recent research efforts have emphasized the clearance of activated HSCs by apoptosis, senescence, or reversion to the quiescent state. LPS induces human HSC activation directly and contributes to

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure.

Hongxia Liang et al.

ACS nano, 12(7), 6536-6544 (2018-06-27)

Acute liver failure is a critical condition characterized by global hepatocyte death and often time needs a liver transplantation. Such treatment is largely limited by donor organ shortage. Stem cell therapy offers a promising option to patients with acute liver

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