MABT189

Anti-Delta3 Antibody, clone 1E7.2

clone 1E7.2, from mouse

• Synonyme(s) : Delta-like protein 3, Drosophila Delta homolog 3, Delta3
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 1E7.2, monoclonal
• Espèces réactives: human
• Technique(s): flow cytometry: suitable; western blot: suitable
• Isotype: IgMκ
• Numéro d'accès NCBI: NP_058637
• Numéro d'accès UniProt: Q9NYJ7
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... DLL3(10683)

Description

Description générale

DLL3, also known as Delta like ligand 3, is a transmembrane Delta-like protein principally found in the Golgi apparatus and endosomes where it promotes Notch family receptor degradation to inhibit primary neurogenesis. DLL3 is one of five DSL proteins that bind to the Notch receptor. Notch signaling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands family members are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in the DLL3 gene causes autosomal recessive spondylocostal dysostosis.

Immunogène

Linear peptide corresponding to human Delta3.

Application

Flow Cytometry Analysis: 0.1 µg from a representative lot detected Delta3 in HEK293 cells.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

This Anti-Delta3 Antibody, clone 1E7.2 is validated for use in WB, FC for the detection of Delta3.

Qualité

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Delta3 on 10 µg of human liver tissue lysate.

Description de la cible

~65 kDa observed

Forme physique

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Human liver tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable