MAB3536
Anti-Lamin B2 Antibody, clone LN43
clone LN43, Chemicon®, from mouse
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
culture supernatant
Type de produit anticorps
primary antibodies
Clone
LN43, monoclonal
Espèces réactives
mouse, hamster, human, Xenopus
Fabricant/nom de marque
Chemicon®
Technique(s)
flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... LMNB2(84823)
Description générale
Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2.
Spécificité
Lamin B2. Recognizes an epitope located in the C-terminal part of lamin B2.
Immunogène
Detergent insoluble fraction of potoroo cell line PtK1
Application
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
This Anti-Lamin B2 Antibody, clone LN43 is validated for use in FC, WB, IH for the detection of Lamin B2.
Western blotting: 1:100-1:1,000; nuclear preparations recommended; detects 67-68kDa lamin B2 protein
Immunocytochemistry on fixed cells (methanol/acetone fixation): 1:100-1:200.Flow cytometry: 1:100-1:200.
Optimal working dilutions must be determined by the end user.
Immunocytochemistry on fixed cells (methanol/acetone fixation): 1:100-1:200.Flow cytometry: 1:100-1:200.
Optimal working dilutions must be determined by the end user.
Forme physique
Format: Purified
Purified culture supernatant. Liquid in PBS containing 0.09% sodium azide.
Stockage et stabilité
Maintain -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Sara A Georges et al.
Cancer research, 68(24), 10105-10112 (2008-12-17)
Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G(1)
P Hozák et al.
Journal of cell science, 108 ( Pt 2), 635-644 (1995-02-01)
The nuclear lamina forms a protein mesh that underlies the nuclear membrane. In most mammalian cells it contains the intermediate filament proteins, lamins A, B and C. As their name indicates, lamins are generally thought to be confined to the
Shannon E Weigum et al.
BMC neuroscience, 4, 6-6 (2003-04-17)
Nuclear objects that have in common the property of being recognized by monoclonal antibodies specific for phosphoprotein epitopes and cytoplasmic intermediate filaments (in particular, SMI-31 and RT-97) have been reported in glial and neuronal cells, in situ and in vitro.
Frédéric Dallaire et al.
Journal of virology, 83(23), 12172-12184 (2009-09-18)
It has been known for some time that the human adenovirus serotype 5 (Ad5) E4orf6 and E1B55K proteins work in concert to degrade p53 and to regulate selective export of late viral mRNAs during productive infection. Both of these functions
Oliver Dreesen et al.
The Journal of cell biology, 200(5), 605-617 (2013-02-27)
The nuclear lamina consists of A- and B-type lamins. Mutations in LMNA cause many human diseases, including progeria, a premature aging syndrome, whereas LMNB1 duplication causes adult-onset autosomal dominant leukodystrophy (ADLD). LMNB1 is reduced in cells from progeria patients, but
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