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MAB1924

Sigma-Aldrich

Anti-Laminin α5 Antibody, clone 4C7

ascites fluid, clone 4C7, Chemicon®

Synonyme(s) :

Anti-AA408760, Anti-AA408762, Anti-AI853660, Anti-laminin-511, Anti-mKIAA0533

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

4C7, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotype

IgG2a

Numéro d'accès NCBI

NM_005560.3

Numéro d'accès UniProt

O15230

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... LAMA2(3908)

Spécificité

Reacts with the globular domain of the alpha5 chain of intact laminin and blocks the neurite stimulating activity of laminin. This antibody was originally thought to recognize laminin alpha 1 or A, but further characterization has confirmed its specificity for the laminin alpha 5 chain [see Tiger, C.F. (1997) J. Biol. Chem. 272: 28590].

Application

Anti-Laminin α5 Antibody, clone 4C7 is an antibody against Laminin α5 for use in ELISA, IH & IP.
ELISA (50% maximal binding to human laminin): >1:11,000.

Immunofluorescence - tissue staining pattern is most consistent with that observed for laminin alpha5 in the mouse(Miner et al., 1997)

Affinity chromatography

Immunoprecipitation

Does not work for Western blotting

Optimal working dilutions must be determined by end user.

Forme physique

UnPurified mouse ascites containing no preservatives.

Remarque sur l'analyse

Control
Developing striated muscle tissue

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle.
Klinge L, Harris J, Sewry C, Charlton R, Anderson L, Laval S, Chiu YH, Hornsey M et al.
Muscle and Nerve null
Titin mutation segregates with hereditary myopathy with early respiratory failure.
Gerald Pfeffer,Hannah R Elliott,Helen Griffin,Rita Barresi,James Miller,Julie Marsh et al.
Brain null
Y He et al.
Neurology, 57(7), 1319-1322 (2001-10-10)
The authors report a case of congenital muscular dystrophy with mild nonprogressive muscle weakness, white matter hypodensity, and absence of the laminin alpha2 chain in muscle fibers with two antibodies, but not with four others. They identified mutations in LAMA2
Jamie L Maciaszek et al.
Biophysical journal, 102(5), 1137-1143 (2012-03-13)
Collapse and sudden death in physical training are the most serious complications of sickle cell trait (SCT). There is evidence that erythrocytes in SCT patients aggregate during strenuous exercise, likely because of adhesive interactions with the extracellular matrix (ECM) and
S Matsubara et al.
Neuromuscular disorders : NMD, 9(6-7), 388-398 (1999-11-02)
Despite the recent advance in genetic study of Fukuyama-type congenital muscular dystrophy (FCMD), the mechanism of muscle degeneration in the disease remains unclear. To clarify it, muscle biopsies from six cases of FCMD were subjected to immunohistochemical and ultrastructural studies.
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