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Key Documents

ABN174

Sigma-Aldrich

Anti-MNX1 (HB9) Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse, human

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_005506

Numéro d'accès UniProt

P50219

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MNX1(3110)

Description générale

Motor neuron and pancreas homeobox protein 1 (MNX1) is a transcription factor that is predominantly expressed in lymphoid and pancreatic tissues. It is involved in the development and function of the pancreas. Abnormal expression of MNX1 results in an autosomal dominant condition known as Currarino syndrome.

Spécificité

Other homologies: Zebrafish (94% sequence homology) and Xenopus (89% sequence homology).
This antibody recognizes a portion of the Homeobox DNA binding domain.

Immunogène

KLH-conjugated linear peptide corresponding to human MNX1.

Application

Anti-MNX1 (HB9) Antibody detects level of MNX1 (HB9) & has been published & validated for use in Western Blotting & IHC.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected MNX1 in human pancreas and mouse cerebral cortex tissues.
Research Category
Neuroscience
Research Sub Category
Transcription Factors

Qualité

Evaluated by Western Blot in PANC-1 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected MNX1 in 10 µg of PANC-1 cell lysate.

Description de la cible

~50 kDa observed. An uncharacterized band may appear at ~48 kDa in some lysates.

Forme physique

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
PANC-1 cell lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Gonzalo Perez-Siles et al.
Disease models & mechanisms, 13(2) (2020-01-24)
ATP7A encodes a copper-transporting P-type ATPase and is one of 23 genes in which mutations produce distal hereditary motor neuropathy (dHMN), a group of diseases characterized by length-dependent axonal degeneration of motor neurons. We have generated induced pluripotent stem cell
Toma Tebaldi et al.
Molecular cell, 71(2), 256-270 (2018-07-22)
The RNA-binding protein HuD promotes neurogenesis and favors recovery from peripheral axon injury. HuD interacts with many mRNAs, altering both stability and translation efficiency. We generated a nucleotide resolution map of the HuD RNA interactome in motor neuron-like cells, identifying

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