ABE794

Anti-PCBP4 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Poly(rC)-binding protein 4, Alpha-CP4, PCBP4
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Technique(s): immunocytochemistry: suitable; immunofluorescence: suitable; western blot: suitable
• Numéro d'accès UniProt: P57723
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PCBP4(57060)

Description

Description générale

PCBP4 (also known as MCG10, Poly (rC) binding protein 4 and alpha-CP4) is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. PCBP4 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of PCBP4 has been observed in many forms of lung cancer, leading to speculation that PCBP4 can act as a tumor suppressor.

Immunogène

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to a 17 amino acid peptide near the C-terminus of human PCBP4.

Application

Anti-PCBP4 Antibody is a highly specific rabbit polyclonal antibody, that targets Poly (rC) binding protein 4 & has been tested in western blotting, ICC & Immunofluorescence.

Immunocytochemistry Analysis: 1 μg/mL from a representative lot detected PCBP4 in HeLa cells.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PCBP4 in HeLa cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Qualité

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected PCBP4 in HeLa cell lysate.

Description de la cible

~51 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable