ABD122
Anti-Dishevelled Antibody
serum, from rabbit
Synonyme(s) :
DSH, DVL1, DVL2, DVL3, DSH Homolog 1
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.75
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
rat, mouse, human
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... DVL3(1857)
Description générale
Dishevelled (DVL1), the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation. The protein acts as a transducer molecule for developmental processes, including segmentation and neuroblast specification. Dishevelled plays a role both in canonical and non-canonical Wnt signaling. DVL1 mutation is likely responsible for transformation in neuroblastomas, and the Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene, thus Dishevelled maybe important in these diseases as well.
Spécificité
Recognizes Human, Mouse and Rat Dishevelled 1, 2 and 3.
Immunogène
GST-tagged recombinant protein corresponding to Human Dishevelled.
Application
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in PC12 cells. (Kishida et al., 2007. Dvl regulates endo- and exocytotic processes through binding to synaptotagmin. Genes to Cells, 12, 49–61).
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Developmental Signaling
Developmental Signaling
This Anti-Dishevelled Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Dishevelled.
Qualité
Evaluated by Western Blot in HEK293T cell lysate.
Western Blot Analysis: A 1:1000 of this antibody detected Dishevelled in 10 µg of HEK293T cell lysate.
Western Blot Analysis: A 1:1000 of this antibody detected Dishevelled in 10 µg of HEK293T cell lysate.
Description de la cible
~ 81 kDa observed
Forme physique
Rabbit polyclonal serum containing 0.05% sodium azide.
Unpurified
Stockage et stabilité
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Autres remarques
Concentration: Please refer to lot specific datasheet.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
S Kishida et al.
Molecular and cellular biology, 19(6), 4414-4422 (1999-05-18)
The N-terminal region of Dvl-1 (a mammalian Dishevelled homolog) shares 37% identity with the C-terminal region of Axin, and this related region is named the DIX domain. The functions of the DIX domains of Dvl-1 and Axin were investigated. By
Shosei Kishida et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(1), 49-61 (2007-01-11)
Dvl, an important component of the Wnt signalling pathway, is thought to be involved in synaptogenesis. In this study, we investigated whether Dvl regulates neurotransmitter release. Knockdown of Dvl in PC12 cells suppressed K(+)-induced dopamine release, and this phenotype was
Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase.
Kishida, S; Yamamoto, H; Kikuchi, A
Molecular and cellular biology null
Anja Bufe et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(34) (2021-08-22)
Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating β-catenin target genes. Recent evidence showed that β-catenin-independent Wnt signaling is also required for faithful execution of mitosis. However, the targets and specific functions of mitotic Wnt
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