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Key Documents

AB8230

Sigma-Aldrich

Anti-Syndecan-1 Antibody

serum, from rabbit

Synonyme(s) :

CD138 antigen, heparan sulfate proteoglycan fibroblast growth factor

receptor, syndecan 1, syndecan proteoglycan 1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

serum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, human

Technique(s)

western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SDC1(6382)

Description générale

Syndecan-1, also known as CD138, is a transmembrane (Type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization. Bearing properties of both heparan sulfate and chondroitin sulfate, Syndecan-1 functions as a cell surface proteoglycan membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types.

Spécificité

Cat. No. AB8230 recognizes mouse Syndecan-1.
Predicted to cross react with human, based on 100% sequence homology.
Reactivity with other species has not been tested.

Immunogène

His-tagged, full-length human recombinant Syndecan-1 protein.

Application

Anti-Syndecan-1 Antibody is an antibody against Syndecan-1 for use in WB.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Qualité

Evaluated on a representative lot by Western blot on mouse liver lysate using 1:1000 dilution of Anti-Syndecan-1.

Description de la cible

The expected molecular weight of monomeric Syndecan-1 is ~32 kDa; however, the core protein often migrates as an SDS-stable dimer with an approximate M.W. of 77 kDa Additionally, a high M.W. form of the protein may often be seen between 500-1000 kDa, likely the mature form of Syndecan-1, with all of its heparan and chondroitin sulfate additions. In whole tissues, this mature form often binds tightly to ECM molecules and may require solublization by urea extraction for additional SDS-PAGE analysis (Wilsie, 2006). Triton X-100 or similar mild detergents are sufficient to release the immature precursor forms of Syndecan-1.

Forme physique

Rabbit serum containing 0.05% NaN3.

Stockage et stabilité

Maintain at -20°C for up to 1 year from date of receipt.

Remarque sur l'analyse

Control
Mouse liver lysate

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1


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