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Key Documents

AB6002

Sigma-Aldrich

Anti-MMP-1 Antibody, hinge region

from rabbit, purified by affinity chromatography

Synonyme(s) :

Fibroblast collagenase, Matrix metalloproteinase-1, matrix metallopeptidase 1, interstitial collagenase, matrix metalloprotease 1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_002412

Numéro d'accès UniProt

P03956

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MMP1(4312)

Description générale

All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn2+ binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). MMP1, also known as interstitial collagenase, is the only enzyme able to initiate the breakdown of the interstitial collagens, types I, II, and III.

Spécificité

Additional sequence homology is noted with mouse (81%) and rat (75%).
The antibody recognizes an internal domain of human MMP-1 containing the hinge region. It does not cross react with MMP-2, MMP-9, or MMP-13.

Immunogène

KLH-conjugated synthetic peptide corresponding to the hinge region of human MMP-1.

Application

Anti-MMP-1 Antibody, hinge region is an antibody against MMP-1 for use in WB.

Qualité

Evaluated on a representative lot by Western blot on A431 cell lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected MMP-1 on 10 µg of A431 cell lysate.

Description de la cible

54 kDa In Western Blot, bands around 53 kDa and 51 kDa (proenzyme) are observed in reduced proteins.

Liaison

Replaces: 04-1122

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Fibroblast response to gadolinium: role for platelet-derived growth factor receptor.
Bhagavathula, N; Dame, MK; DaSilva, M; Jenkins, W; Aslam, MN; Perone, P; Varani, J
Investigative Radiology null
Changes in allele-specific association of histone modifications at the imprinting control regions during mouse preimplantation development.
Kim JM, Ogura A
Genesis null
Spatial distribution of histone isoforms on the bovine active and inactive X chromosomes.
G Coppola,A Pinton,E M Joudrey,P K Basrur,W A King
Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation null
Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.
Chaturvedi CP, Hosey AM, Palii C, Perez-Iratxeta C, Nakatani Y, Ranish JA, Dilworth FJ, Brand M
Proceedings of the National Academy of Sciences of the USA null
Wilson Leung et al.
G3 (Bethesda, Md.), 7(8), 2439-2460 (2017-07-02)
The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (>18.7 Mb) in
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