AB16530
Anti-BAFF Antibody, CT
Chemicon®, from rabbit
Synonyme(s) :
TALL-1, THANK, BLyS
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
rat, human, mouse
Fabricant/nom de marque
Chemicon®
Technique(s)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TNFSF13B(10673)
mouse ... Tnfsf13B(24099)
rat ... Tnfsf13B(498666)
Catégories apparentées
Spécificité
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BlyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal kinase) (Moore et al. 1999; Schneider et al. 1999; Shu et al. 1999; Mukhopadhyay et al. 1999). BAFF/BlyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion (Moore et al. 1999; Schneider et al. 1999). Two receptors for BAFF were recently identified and designated TACI and BCMA (Gross et al. 2000). BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases (Gross et al. 2000; Khare et al. 2000). Like TNFalpha and TRAIL, THANK was shown to activate NF-kB and c-jun N-terminal kinase (JNK) and to induce apoptosis (Mukhopadhyay et al. 1999).
Immunogène
Epitope: C-terminus
Rabbit anti-BAFF (C-term) polyclonal antibody was raised against a peptide corresponding to amino acids 254 to 269 of human BAFF (Moore et al. 1999; Schneider et al. 1999; Shu et al. 1999; Mukhopadhyay et al. 1999).
Application
Anti-BAFF Antibody, C-terminus detects level of BAFF & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
BCL2 & Inhibition
Western blot: 0.25 to 1 μg/mL.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Forme physique
Format: Purified
Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Stockage et stabilité
Maintain at 2-8°C in undiluted aliquots for up to 12 months.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
S D Khare et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(7), 3370-3375 (2000-03-15)
TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a
P Schneider et al.
Immunity, 7(6), 831-836 (1998-01-16)
TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and
J A Gross et al.
Nature, 404(6781), 995-999 (2000-05-09)
B cells are important in the development of autoimmune disorders by mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cells. zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor
H B Shu et al.
Journal of leukocyte biology, 65(5), 680-683 (1999-05-20)
Members of the tumor necrosis factor (TNF) family play important roles in modulation of immune responses. We describe the identification and cloning of a novel TNF family member that has been designated as TALL-1. TALL-1 is a 285-amino acid type
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