AB15322

Anti-Nicotinic Acetylcholine Receptor α4 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Cholinergic receptor, nicotinic, alpha 4 (neuronal), Cholinergic receptor, nicotinic, alpha polypeptide 4, Neuronal nicotinic acetylcholine receptor alpha-4 subunit, Neuronal acetylcholine receptor subunit alpha-4
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human, rat, mouse
• Technique(s): western blot: suitable
• Numéro d'accès NCBI: NP_077330
• Numéro d'accès UniProt: P09483
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CHRNA4(1137)

Description

Description générale

Nicotinic acetylcholine receptors, or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons. nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh) and is also opened by nicotine. After binding ACh, the nAChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. nAChRs are present in many tissues in the body: the neuronal receptors are present in the central nervous system and the peripheral nervous system; and the neuromuscular receptors are found in the neuromuscular junctions of somatic muscles. Neuronal AChR is composed of two different types of subunits: alpha (α) and beta (β).

Spécificité

This antibody recognizes Nicotinic Acetylcholine Receptor α4.

Immunogène

Epitope: Extracellular Domain

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from residues of Nicotinic Acetylcholine Receptor α4.

Application

Detect Nicotinic Acetylcholine Receptor α4 using this Anti-Nicotinic Acetylcholine Receptor α4 Antibody validated for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Qualité

Evaluated by Western Blot in rat e16 brain lysate.
Western Blot Analysis: : 1:1,000 dilution of this lot detected Nicotinic Acetylcholine Receptor α4 in 10 µg of e16 rat brain lysate.

Description de la cible

Approx. 55 kDa

Forme physique

Antigen Affinity Purified

Rabbit purified polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Maintain refrigerated at 2-8°C for up to 12 months from date of receipt.

Remarque sur l'analyse

Control
Rat e16 brain lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable