8.01949

N-Bromosuccinimide

for peptide synthesis

• Synonyme(s) : N-Bromosuccinimide, NBS
• Formule empirique (notation de Hill): C₄H₄BrNO₂
• Numéro CAS: 128-08-5
• Poids moléculaire : 177.98
• Numéro MDL: MFCD00005510
• Code UNSPSC : 12352115
• Numéro de classement CE : 204-877-2
• Nomenclature NACRES : NA.22

Propriétés

• product name: N-Bromosuccinimide, for synthesis
• Pression de vapeur: 14.8 hPa ( 20 °C)
• Niveau de qualité: 200
• Forme: powder
• Puissance: >2000 mg/kg LD₅₀, oral (Rat)
• Pertinence de la réaction: reagent type: oxidant
• Pf: 174-179 °C
• Solubilité: 14.8 g/L (decomposition)
• Densité: 2.1 g/cm³ at 20 °C
• Masse volumique apparente: 750 kg/m³
• Température de stockage: 2-8°C
• InChI: 1S/C4H4BrNO2/c5-6-3(7)1-2-4(6)8/h1-2H2
• Clé InChI: PCLIMKBDDGJMGD-UHFFFAOYSA-N

Description

Application

• Mechanistic study on iodine-catalyzed aromatic bromination of aryl ethers by N-bromosuccinimide: This study explores the roles of NBS in organic synthesis, particularly in radical and electrophilic substitutions (Pramanick et al., 2017).
• One‐Pot Protocol for the Synthesis of Imidazoles and Quinoxalines using N‐Bromosuccinimide: This paper reports a green, efficient synthesis of heterocycles mediated by NBS (Pardeshi et al., 2017).
• N-Bromosuccinimide as an Interfacial Alleviator for Br/I Exchange in Perovskite for Solar Cell Fabrication: This research demonstrates the use of NBS in improving the crystallization and defect passivation in perovskite solar cells (Pegu et al., 2021).
• N‐Bromosuccinimide‐Mediated Radical Cyclization of 3‐Arylallyl Azides: Synthesis of 3‐Substituted Quinolines: Discusses the application of NBS under visible light irradiation to synthesize quinolines (Wang et al., 2015).
• N-Bromosuccinimide mediated synthesis of triazatruxenes from indoles: This study highlights the cyclotrimerization of indoles using NBS, demonstrating its utility as a reagent in complex organic transformations (Toworakajohnkun et al., 2017).

Remarque sur l'analyse

Assay (iodometric): ≥ 99.0 %
Identity (IR): passes test

Informations sur la sécurité

• Pictogrammes: GHS03,GHS05,GHS07,GHS08,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H272 - H290 - H315 - H317 - H319 - H341 - H400
• Conseils de prudence: P210 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Eye Irrit. 2 - Met. Corr. 1 - Muta. 2 - Ox. Sol. 3 - Skin Irrit. 2 - Skin Sens. 1B
• Code de la classe de stockage: 5.1B - Oxidizing hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable