647926-M

Trichostatin A, Streptomyces sp.

InSolution, ≥98%, reversible inhibitor of histone deacetylase

• Synonyme(s) : InSolution Trichostatin A, Streptomyces sp., 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, HDAC Inhibitor IX, TSA
• Formule empirique (notation de Hill): C₁₇H₂₂N₂O₃
• Poids moléculaire : 302.37
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Température de stockage: −20°C

Description

Description générale

A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC₅₀ = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.

Actions biochimiques/physiologiques

Primary Target
histone deactylase

Target IC₅₀: 73 nM inhibiting IL-2 gene expression in Jurkat cells

Avertissement

Toxicity: Harmful (C)

Forme physique

A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Point d'éclair (°C): 87 °C - closed cup - (Dimethylsulfoxide)