530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• Synonyme(s) : PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• Formule empirique (notation de Hill): C₉H₁₅NO₃
• Numéro CAS: 5608-24-2
• Poids moléculaire : 185.22
• Numéro MDL: MFCD04974196
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (NMR)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: off-white
• Solubilité: water: 2 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• Clé InChI: RFBVBRVVOPAAFS-UHFFFAOYSA-N

Description

Description générale

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.

Actions biochimiques/physiologiques

Primary Target
Restores biochemical and biological function to mutant p53

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H334
• Conseils de prudence: P261 - P264 - P270 - P284 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral - Resp. Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable