5.08507

Isradipine

• Synonyme(s) : Isradipine, L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
• Formule empirique (notation de Hill): C₁₉H₂₁N₃O₅
• Numéro CAS: 75695-93-1
• Poids moléculaire : 371.39
• Numéro MDL: MFCD00153820
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 100 mM; ethanol: 50 mM
• Température de stockage: 2-8°C
• InChI: 1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
• Clé InChI: HMJIYCCIJYRONP-UHFFFAOYSA-N

Description

Description générale

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Actions biochimiques/physiologiques

Primary Target
CaV

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Chan, C. S. et al. 2007. Nature.447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708.
Koschak, A. et al. 2003. J. Neurosci.23, 6041.
Koschak, A. et al. 2001. J. Biol Chem276, 22100.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable