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Key Documents

481990

Sigma-Aldrich

Nigericin, Sodium Salt, Streptomyces hygroscopicus

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Synonyme(s) :

Nigericin, Sodium Salt, Streptomyces hygroscopicus, Antibiotic K178

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About This Item

Formule empirique (notation de Hill):
C40H67O11 · Na
Numéro CAS:
28643-80-3
Poids moléculaire :
746.94
Numéro MDL:
MFCD00036825
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (TLC)

Forme

lyophilized

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Solubilité

chloroform: soluble
ethanol: soluble
ethyl acetate: soluble

Conditions d'expédition

ambient

Température de stockage

2-8°C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1

Clé InChI

MOYOTUKECQMGHE-KKCUGXASSA-M

Description générale

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
Disrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Disrupts the membrane potential and stimulates ATPase activity in mitochondria.
Product does not compete with ATP.
Reversible: no

Avertissement

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Moriyama, Y., et al. 1994. J. Biochem.115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem.265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett.127, 112.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H319

Classification des risques

Acute Tox. 3 Oral - Eye Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Sandip Ghosh et al.
Biosensors & bioelectronics, 155, 112115-112115 (2020-03-29)
Fluorescence based intracellular pH nanoprobes have been developed that overcomes the limitations imposed by shallow penetration depth of ultraviolet excitation, photostability, phototoxicity, and interference from background autofluorescence. In this study, we have constructed a Förster Resonance Energy Transfer (FRET) based
Liang Tao et al.
Cell death and differentiation, 28(4), 1418-1433 (2020-11-20)
Hepatocyte cell death and liver inflammation have been well recognized as central characteristics of nonalcoholic steatohepatitis (NASH), however, the underlying molecular basis remains elusive. The kinase receptor-interacting protein 1 (RIP1) is a multitasking molecule with distinct functions in regulating apoptosis
Pan Pan et al.
Nature communications, 12(1), 4664-4664 (2021-08-04)
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3

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