400600

L-N⁵-(1-Iminoethyl)ornithine dihydrochloride

≥98% (TLC), solid, eNOS inhibitor, Calbiochem^®

• Synonyme(s) : L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride, L-NIO, 2HCl
• Formule empirique (notation de Hill): C₇H₁₅N₃O₂ · 2HCl
• Numéro CAS: 159190-44-0
• Poids moléculaire : 246.13
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.77

Propriétés

• product name: L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride, A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.
• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C7H15N3O2.2ClH/c1-5(8)10-4-2-3-6(9)7(11)12;;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);2*1H/t6-;;/m0../s1
• Clé InChI: RYCMAAFECCXGHI-ILKKLZGPSA-N

Description

Description générale

A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC₅₀ = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC₅₀ = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC₅₀ = 19.5 mg/kg).

Cell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC₅₀ = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC₅₀ = 19.5 mg/kg).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
eNOS

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 500 nM against endothelial nitric oxide synthase (eNOS); 2 µM against acetylcholine-induced relaxation of rat aorta rings; EC50 = 19.5 mg/kg for a dose-dependent increase in mean arterial blood pressure in the rat

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Autres remarques

Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
Rees, D.D., et al. 1990. Br. J. Pharmacol.101, 746.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable