370677

Guanosine 3′,5′-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.

• Synonyme(s) : Guanosine 3′,5′-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt, Rp-8- pCPT-cGMPS, TEA, PKG Inhibitor III
• Formule empirique (notation de Hill): C₁₆H₁₅ClN₅O₆PS₂ · xC₆H₁₅N
• Poids moléculaire : 503.88 (free acid basis)
• Code UNSPSC : 41106305
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥99% (HPLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Solubilité: water: 0.5 mg/mL; DMSO: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PKG1α

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Abd Alla, S., et al. 1996. Eur. J. Biochem.241, 498.
Lee, S.J., et al. 1996. Dev. Biol.180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Willmott, N., et al. 1996. J. Biol. Chem.271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.

Informations légales

Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable