361548

GSK-3β Inhibitor VII

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : GSK-3β Inhibitor VII, α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
• Formule empirique (notation de Hill): C₈H₆Br₂O
• Numéro CAS: 99-73-0
• Poids moléculaire : 277.94
• Numéro MDL: MFCD00000200
• Code UNSPSC : 12352100
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• InChI: 1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
• Clé InChI: FKJSFKCZZIXQIP-UHFFFAOYSA-N

Description

Description générale

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.

Actions biochimiques/physiologiques

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.5 µM against GSK-3β

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Conde, S., et al. 2003. J. Med. Chem.46, 4631.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H314
• Conseils de prudence: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classification des risques: Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable