343922

5-Fluorouracil

≥98% (HPLC), solid, antitumor agent, Calbiochem^®

• Synonyme(s) : 5-Fluorouracil, 5-FU
• Formule empirique (notation de Hill): C₄H₃FN₂O₂
• Numéro CAS: 51-21-8
• Poids moléculaire : 130.08
• Numéro MDL: MFCD00006018
• Code UNSPSC : 12171500
• Nomenclature NACRES : NA.77

Propriétés

• product name: 5-Fluorouracil, Potent antitumor agent.
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: hot water: 1 mg/mL; methanol: 1 mg/mL; DMF: 5 mg/mL; DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• Clé InChI: GHASVSINZRGABV-UHFFFAOYSA-N

Description

Description générale

Potent antitumor agent that inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis of human colon cancer cell lines.

Potent antitumor agent. Inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis in human colon cancer cell lines.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Aminoisobutyrate-pyruvate aminotransferase

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Pressacco, J., et al. 1996. Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H351
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral - Carc. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3