211200

CAPE

A cell-permeable active component of propolis from honeybee hives.

• Synonyme(s) : CAPE, Caffeic Acid Phenethyl Ester, Synthetic
• Formule empirique (notation de Hill): C₁₇H₁₆O₄
• Numéro CAS: 104594-70-9
• Poids moléculaire : 284.31
• Numéro MDL: MFCD00866470
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to off-white
• Solubilité: DMSO: 200 mg/mL; ethanol: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
• Clé InChI: SWUARLUWKZWEBQ-VQHVLOKHSA-N

Description

Description générale

A cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK) and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation.

A cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK), and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
HIV-integrase

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Nicklaus, M.C., et al. 1997. J. Med. Chem.40, 920.
Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 9090.
Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2399.
Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable